This page tracks new and upcoming treatment options for Sjogren’s syndrome (SS). What’s in development? What’s promising? What’s available soon? Current topics include CP-25, CFZ533, VAY736, JAK inhibitors, RSLV-132, nuclease therapy, tofacitinib, LOU064, LO2A, anti-CD40 antibodies, AT-RvD1, fecal microbial transplant (FMT), RC-18, iguratimod, stem cells, BMP inhibitors, ustekinumab, AQP5, SS-1, and more. Jump to section: News, Research, Clinical Trials
Last updated: 6 months ago
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News
- Signaling Molecule IL-38 Can Reduce Inflammation, May Be Therapy Target, Study Finds Sep 30, 2020
- Arginase 1 Protein May Protect from Sjögren’s-related Dryness, Mouse Study Suggests Sep 21, 2020
- Ask the Expert: CBD Oil and Sjögren’s Aug 12, 2020
- OMRF needs participants for Sjögren’s Syndrome study Aug 7, 2020
- University of Queensland and CSL Limited partner up to progress treatments for Sjogren’s syndrome Jul 20, 2020
- Luminary Therapeutics, Case Western Team Up to Develop New CAR T-Cell Therapy for Sjogren’s Jul 15, 2020
- Two Projects Using Hydrogel Biomaterials to Stimulate Tissue Regeneration Move Forward with New Funding Jul 14, 2020
- Luminary Therapeutics and Case Western Reserve University enter formal collaboration for development of BAFF CAR-T (LMY-920) for Sjogren’s Syndrome Jul 7, 2020
- Study identifies CP-25 as a potential drug for the treatment of primary Sjögren’s syndrome Jul 6, 2020
- How the Hydroxychloroquine (HCQ) Shortage Highlights Sjogren’s Neglect Jun 16, 2020
- The 2020 Sjögren’s Foundation National Patient Conference (June 26 & June 27, 2020) is going Virtual Jun 3, 2020
- Wize Pharma Completes Phase IV Study of LO2A for the Treatment of Dry Eye Syndrome in Patients with Sjögren’s Syndrome May 7, 2020
- Targeted Approach for Tackling Sjögren’s Syndrome – Small molecules restore salivary function in mice Apr 27, 2020
- Abatacept Fails Clinical Trial for Sjögren’s Syndrome Mar 24, 2020
- Phase 4 Trial of Treatment for Dry Eyes, LO2A Drops, in Sjögren’s Patients Fully Enrolled Jan 23, 2020
- Wize Pharma Completes Patient Enrollment In Phase 4 Study Of LO2A for the Treatment of Dry Eye Syndrome in Patients With Sjögren’s Syndrome Jan 21, 2020
- Potential Sjogren’s Therapy LOU064 Shows Promise in Early Lab Studies, Healthy Volunteers Jan 16, 2020
- Hope for patients with rare Sjögren’s syndrome Oct 29, 2019
- The Challenge of Identifying Sjogren’s Syndrome Sep 9, 2019
- AT-RvD1 Restores Function of Salivary Glands, Decreases Harmful T-cells in Mouse Model of Sjögren’s Apr 2, 2019
Research
- Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren’s syndrome Sep 25, 2020
- Blockade of Th17 response by IL-38 in primary Sjögren’s syndrome Sep 18, 2020
- Gpr125 Plays Critical Roles in Lacrimal Myoepithelia and Tear Film [Preprint] Sep 16, 2020
- CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases Sep 3, 2020
- Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms Aug 31, 2020
- Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome Aug 26, 2020
- MicroRNAs and Autoimmune-Mediated Eye Diseases Aug 20, 2020
- The applications of androgen in the treatment of dry eye disease: a systematic review of clinical studies Aug 18, 2020
- Nuclease Therapy Improves Severe Fatigue in Primary Sjögren’s Syndrome: A Randomized Clinical Trial Aug 15, 2020
- Advances in treatments for Sjögren’s syndrome: the glass is half full Aug 3, 2020
- Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren’s syndrome Jul 30, 2020
- Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives Jul 26, 2020
- Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren’s Syndrome Jul 21, 2020
- Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy Jul 20, 2020
- Long-term hydroxychloroquine therapy improves the quality of sleep in patients with primary Sjögren’s syndrome: a real-world study [PDF] Jul 20, 2020
- Lung Involvement in Primary Sjögren’s Syndrome-An Under-Diagnosed Entity Jul 16, 2020
- Novel Cytokine Multiplex Assay for Tear Fluid Analysis in Sjogren’s Syndrome Jul 13, 2020
- The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases such as Sjogren’s Syndrome Jul 7, 2020
- CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration Jul 3, 2020
- M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren’s syndrome Jul 2, 2020
- Iguratimod treatment reduces disease activity in early primary Sjögren’s syndrome Jul 2, 2020
- Sjogren’s Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports Jul 1, 2020
- The efficacy and mechanism for action of iguratimod in primary Sjögren’s syndrome patients Jul 1, 2020
- Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren’s syndrome Jul 1, 2020
- Insight into Salivary Gland Aquaporins: AQP5 represents a potential therapeutic target for the treatment of xerostomia (dry mouth) Jun 25, 2020
- Characterization of antiapoptotic microRNAs in primary Sjögren’s syndrome: potential targets for the treatment of pSS Jun 23, 2020
- Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndrome Jun 22, 2020
- Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases including Sjögren syndrome (SjS) Jun 17, 2020
- Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome Jun 15, 2020
- Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren’s syndrome Jun 7, 2020
- Efficacy of Belimumab in Primary Sjögren’s Syndrome: A Systematic Review May 22, 2020
- Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren’s Syndrome May 14, 2020
- Immunobiology of T Cells in Sjögren’s Syndrome: summary of research progress to provide insights for clinical treatment May 11, 2020
- Clinical significance of progranulin correlated with serum soluble Oxford 40 ligand in primary Sjögren’s syndrome: PGRN and sOX40L serve as an important markers of pSS May 2, 2020
- Fibromyalgia, Sjogren’s & Depression: Linked? Apr 21, 2020
- Cysteine cathepsins as therapeutic targets in inflammatory diseases Apr 6, 2020
- JAK Inhibitors: Prospects in Connective Tissue Diseases including Sjögren’s Syndrome Mar 28, 2020
- Total glucosides of paeony (TGP) alleviates Sjogren’s syndrome through inhibiting inflammatory responses in mice Mar 6, 2020
- Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome Mar 5, 2020
- Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren’s syndrome Feb 15, 2020
- Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions Jan 19, 2020
- Alleviating effect of CP-25 in antigen-induced experimental Sjögren’s syndrome by modulating B lymphocyte migration via CXCR5-GRK2-ERK/p38 signaling pathway Jan 16, 2020
- Primary Sjogren’s syndrome: a great masquerader Dec 29, 2019
- A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren’s syndrome Dec 28, 2019
- A213, a RORγt antagonist, improves Sjögren’s syndrome-like sialadenitis through downregulation of CD25 Dec 14, 2019
- Sjögren’s syndrome: Old and new therapeutic targets Dec 9, 2019
- LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjögren’s syndrome-like autoimmune response Nov 19, 2019
- Associations of Anti-Aquaporin 5 Autoantibodies with Features of Sjögren’s Syndrome: Screening may reveal subgroups of SS for targeted therapy Nov 3, 2019
- Common and rare forms of vasculitis associated with Sjögren’s syndrome Oct 21, 2019
- Primary Sjögren’s syndrome and the eye: update regarding pathogenesis, diagnosis, investigative procedures, and treatment options Oct 18, 2019
- Symptom-based stratification of patients with primary Sjögren’s syndrome: exploring new subtypes Oct 1, 2019
- Immune checkpoint molecules: Possible future therapeutic implications in autoimmune diseases such as Sjögren’s syndrome Sep 26, 2019
- Saliva microbiome in primary Sjögren’s syndrome reveals distinct set of disease-associated microbes Sep 12, 2019
- Recent advances in the search for a targeted immunomodulatory therapy for primary Sjögren’s syndrome Aug 29, 2019
- Biologics in Sjögren’s syndrome Aug 12, 2019
- Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome: CatS inhibition may represent a promising novel treatment strategy in pSS Jul 18, 2019
- Potential therapeutic applications of exosomes in different autoimmune diseases including Sjogren’s syndrome Jun 19, 2019
- Sjögren’s syndrome update: Clinical and therapeutic aspects Apr 23, 2019
Clinical Trials
- Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients Sep 14, 2020
- TrueTear in Sjogren’s Disease Patients Aug 25, 2020
- Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjögren’s Syndrome Aug 6, 2020
- Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren’s Syndrome Aug 6, 2020
- Involvement of Immune Cells Derived From the Intestine in Sjogren’s Syndrome Aug 4, 2020
- Intravenous Immunoglobulins for the Treatment of Primary Sjögren’s Syndrome Associated Painful Sensory Neuropathies Jul 27, 2020
- Fecal Microbial Transplant (FMT) for Sjogren’s Syndrome [Completed] Jun 5, 2020
- Safety and Efficacy of VAY736 in Patients With Primary Sjogren’s Syndrome (pSS) May 22, 2020
- A Phase 2 Study to Evaluate the Safety and Efficacy of LOU064 in Patients With Moderate to Severe Sjögren’s Syndrome May 19, 2020
- Rebamipide for the Treatment of Xerostomia (Dry Mouth) in Sjögren Syndrome Mar 31, 2020
- Pilot Trial of Ustekinumab for Primary Sjögren’s Syndrome Mar 18, 2020
- A Clinical Trial to Evaluate the Safety and Efficacy of Traditional Chinese Medicine in Sjögren’s Syndrome [Completed] Oct 1, 2019
- A Study of TACI-antibody Fusion Protein Injection (RC18) in Subjects With Primary Sjögren’s Syndrome Sep 18, 2019
- An Open-Label Phase 2 Study of INCB050465 in Participants With Primary Sjögren’s Syndrome Sep 16, 2019
- A Study of RSLV-132 in Subjects With Primary Sjogren’s Syndrome (RSLV-132) Sep 10, 2019
- Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjögren’s Syndrome (TWINSS) Apr 9, 2019
