Category: Research

Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren’s syndrome

https://pubmed.ncbi.nlm.nih.gov/33025899/ https://www.ncbi.nlm.nih.gov/pubmed/33025899?dopt=Abstract TITLE: Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren’s syndrome. DESCRIPTION: Advances, limitations and future perspectives in the diagnosis and management of dry eye in Sjögren’s syndrome. Clin Exp Rheumatol. 2020 Sep 25; Authors: Vehof J, Utheim TP, Bootsma H, Hammond CJ Abstract Primary Sjögren’s syndrome […]

Blockade of Th17 response by IL-38 in primary Sjögren’s syndrome

https://www.sciencedirect.com/science/article/pii/S016158902030482X?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32950755?dopt=Abstract TITLE: Blockade of Th17 response by IL-38 in primary Sjögren’s syndrome. DESCRIPTION: Blockade of Th17 response by IL-38 in primary Sjögren’s syndrome. Mol Immunol. 2020 Sep 17;127:107-111 Authors: Luo D, Chen Y, Zhou N, Li T, Wang H Abstract BACKGROUND: T helper 17 (Th17) cell responses were involved in the pathophysiology of primary […]

CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases

https://www.nature.com/articles/s41401-020-00510-6 https://www.ncbi.nlm.nih.gov/pubmed/32884075?dopt=Abstract TITLE: CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. DESCRIPTION: Related Articles CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacol Sin. 2020 Sep […]

Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms

https://www.mdpi.com/2077-0383/9/9/2821/htm https://www.ncbi.nlm.nih.gov/pubmed/32878252?dopt=Abstract TITLE: Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms. DESCRIPTION: Related Articles Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms. J Clin Med. 2020 Aug 31;9(9): Authors: Sisto M, Ribatti D, Lisi S Abstract Sjögren’s syndrome (SS) is a systemic autoimmune inflammatory disease with a […]

Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome

https://casereports.bmj.com/content/13/8/e234681 https://www.ncbi.nlm.nih.gov/pubmed/32847874?dopt=Abstract TITLE: Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome. DESCRIPTION: Related Articles Adjuvant rituximab improves sensory ataxia in CIDP-related Sjögren syndrome. BMJ Case Rep. 2020 Aug 26;13(8): Authors: Rocha R, Correia F, Santos A, Martins J Abstract Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune neuropathy characterised by insidious onset, progressive course, […]

MicroRNAs and Autoimmune-Mediated Eye Diseases

https://www.frontiersin.org/articles/10.3389/fcell.2020.00818/full https://www.ncbi.nlm.nih.gov/pubmed/32974350?dopt=Abstract TITLE: MicroRNAs and Autoimmune-Mediated Eye Diseases. DESCRIPTION: Related Articles MicroRNAs and Autoimmune-Mediated Eye Diseases. Front Cell Dev Biol. 2020;8:818 Authors: Wei Y, Li N, Zhao L, Yang C, Ma B, Li X, Wei R, Nian H Abstract MicroRNAs (miRNAs) are evolutionarily conserved short non-coding RNAs that act at post-transcriptional regulation of gene expression […]

The applications of androgen in the treatment of dry eye disease: a systematic review of clinical studies

https://www.jstage.jst.go.jp/article/endocrj/advpub/0/advpub_EJ20-0178/_article https://www.ncbi.nlm.nih.gov/pubmed/32814731?dopt=Abstract TITLE: The applications of androgen in the treatment of dry eye disease: a systematic review of clinical studies. DESCRIPTION: Related Articles The applications of androgen in the treatment of dry eye disease: a systematic review of clinical studies. Endocr J. 2020 Aug 18;: Authors: Wang L, Deng Y Abstract Androgen regulates the function […]

Nuclease Therapy Improves Severe Fatigue in Primary Sjögren’s Syndrome: A Randomized Clinical Trial

https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41489 https://www.ncbi.nlm.nih.gov/pubmed/32798283?dopt=Abstract TITLE: Nuclease Therapy Improves Severe Fatigue in Primary Sjögren’s Syndrome: A Randomized Clinical Trial. DESCRIPTION: Nuclease Therapy Improves Severe Fatigue in Primary Sjögren’s Syndrome: A Randomized Clinical Trial. Arthritis Rheumatol. 2020 Aug 15;: Authors: Posada J, Valadkhan S, Burge D, Davies K, Tarn J, Casement J, Jobling K, Gallagher P, Wilson D, Barone […]

Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren’s syndrome

https://www.sciencedirect.com/science/article/pii/S0929664620303363?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32741737?dopt=Abstract TITLE: Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren’s syndrome. DESCRIPTION: Related Articles Chinese herbal medicine SS-1 inhibits T cell activation and abrogates TH responses in Sjögren’s syndrome. J Formos Med Assoc. 2020 Jul 30;: Authors: Lee GA, Chang CM, Wu YC, Ma RY, Chen CY, Hsue […]

Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives

https://www.eurekaselect.com/184122/article https://www.ncbi.nlm.nih.gov/pubmed/32713335?dopt=Abstract TITLE: Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives. DESCRIPTION: Related Articles Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives. Curr Stem Cell Res Ther. 2020 Jul 26;: Authors: Gong W, Wang F, He Y, Heath B, Zeng X, Zhang D, Chen Q […]

Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren’s Syndrome

https://www.sciencedirect.com/science/article/abs/pii/S0165247820303539?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32707129?dopt=Abstract TITLE: Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren’s Syndrome. DESCRIPTION: Related Articles Injection of CD40 DNA vaccine ameliorates the autoimmune pathology of Non-obese Diabetic Mice with Sjögren’s Syndrome. Immunol Lett. 2020 Jul 21;: Authors: Zhou YB, Yuan X, Wang QK, Zhang H, Wang GS, Li […]

Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy

https://www.mdpi.com/2077-0383/9/7/2299 https://www.ncbi.nlm.nih.gov/pubmed/32698400?dopt=Abstract TITLE: Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy. DESCRIPTION: Related Articles Current State of Knowledge on Primary Sjögren’s Syndrome, an Autoimmune Exocrinopathy. J Clin Med. 2020 Jul 20;9(7): Authors: Parisis D, Chivasso C, Perret J, Soyfoo MS, Delporte C Abstract Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune […]

Long-term hydroxychloroquine therapy improves the quality of sleep in patients with primary Sjögren’s syndrome: a real-world study [PDF]

http://apm.amegroups.com/article/view/47479/pdf https://www.ncbi.nlm.nih.gov/pubmed/32692242?dopt=Abstract TITLE: Long-term hydroxychloroquine therapy improves the quality of sleep in patients with primary Sjögren’s syndrome: a real-world study. DESCRIPTION: Related Articles Long-term hydroxychloroquine therapy improves the quality of sleep in patients with primary Sjögren’s syndrome: a real-world study. Ann Palliat Med. 2020 Jul 20;: Authors: Guan P, Sun C, Chen Z, Chen J, […]

Lung Involvement in Primary Sjögren’s Syndrome-An Under-Diagnosed Entity

https://www.frontiersin.org/articles/10.3389/fmed.2020.00332/full https://www.ncbi.nlm.nih.gov/pubmed/32766261?dopt=Abstract TITLE: Lung Involvement in Primary Sjögren’s Syndrome-An Under-Diagnosed Entity. DESCRIPTION: Related Articles Lung Involvement in Primary Sjögren’s Syndrome-An Under-Diagnosed Entity. Front Med (Lausanne). 2020;7:332 Authors: Sogkas G, Hirsch S, Olsson KM, Hinrichs JB, Thiele T, Seeliger T, Skripuletz T, Schmidt RE, Witte T, Jablonka A, Ernst D Abstract Interstitial lung disease (ILD) represents […]

Novel Cytokine Multiplex Assay for Tear Fluid Analysis in Sjogren’s Syndrome

https://www.tandfonline.com/doi/abs/10.1080/09273948.2020.1767792?journalCode=ioii20 https://www.ncbi.nlm.nih.gov/pubmed/32657632?dopt=Abstract TITLE: Novel Cytokine Multiplex Assay for Tear Fluid Analysis in Sjogren’s Syndrome. DESCRIPTION: Novel Cytokine Multiplex Assay for Tear Fluid Analysis in Sjogren’s Syndrome. Ocul Immunol Inflamm. 2020 Jul 13;:1-6 Authors: Willems B, Tong L, Minh TDT, Pham ND, Nguyen XH, Zumbansen M Abstract PURPOSE: Sjögren’s syndrome (SS) is an autoimmune disease associated […]

The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases such as Sjogren’s Syndrome

https://www.eurekaselect.com/183529/article https://www.ncbi.nlm.nih.gov/pubmed/32634079?dopt=Abstract TITLE: The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. DESCRIPTION: The role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases. Curr Pharm Des. 2020 Jul 07;: Authors: Martinez GP, Zabaleta ME, Di Giulio C, Charris JE, Mijares MR Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic […]

CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration

https://www.nature.com/articles/s41374-020-0453-0 https://www.ncbi.nlm.nih.gov/pubmed/32620868?dopt=Abstract TITLE: CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration. DESCRIPTION: Related Articles CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration. Lab Invest. 2020 Jul 03;: Authors: Wu H, Chen X, Gu F, Zhang P, Xu […]

M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren’s syndrome

https://insight.jci.org/articles/view/135982 https://www.ncbi.nlm.nih.gov/pubmed/32614803?dopt=Abstract TITLE: M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren’s syndrome. DESCRIPTION: M3 muscarinic acetylcholine receptor reactive Th17 cells in primary Sjögren’s syndrome. JCI Insight. 2020 Jul 02;: Authors: Abe S, Tsuboi H, Kudo H, Asashima H, Ono Y, Honda F, Takahashi H, Yagishita M, Hagiwara S, Kondo Y, Matsumoto I, Sumida […]

Iguratimod treatment reduces disease activity in early primary Sjögren’s syndrome

https://www.tandfonline.com/doi/abs/10.1080/14397595.2020.1789335?journalCode=imor20 https://www.ncbi.nlm.nih.gov/pubmed/32613869?dopt=Abstract TITLE: Iguratimod treatment reduces disease activity in early primary Sjögren’s syndrome: an open-label pilot study. DESCRIPTION: Iguratimod treatment reduces disease activity in early primary Sjögren’s syndrome: an open-label pilot study. Mod Rheumatol. 2020 Jul 02;:1-13 Authors: Chen H, Qi X, Li Y, Wu Q, Shi Q, Wang L, Li J, Zhao L, Zhang […]

Sjogren’s Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports

https://www.cureus.com/articles/28039-sjogrens-syndrome-and-clinical-benefits-of-low-dose-naltrexone-therapy-additional-case-reports https://www.ncbi.nlm.nih.gov/pubmed/32765993?dopt=Abstract TITLE: Sjogren’s Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports. DESCRIPTION: Related Articles Sjogren’s Syndrome and Clinical Benefits of Low-Dose Naltrexone Therapy: Additional Case Reports. Cureus. 2020 Jul 01;12(7):e8948 Authors: Zashin S Abstract Sjogren’s syndrome (SS) is a chronic autoimmune disorder that causes the inflammation of the lacrimal and salivary glands, […]

The efficacy and mechanism for action of iguratimod in primary Sjögren’s syndrome patients

https://link.springer.com/article/10.1007%2Fs10792-020-01490-6 https://www.ncbi.nlm.nih.gov/pubmed/32607949?dopt=Abstract TITLE: The efficacy and mechanism for action of iguratimod in primary Sjögren’s syndrome patients. DESCRIPTION: Related Articles The efficacy and mechanism for action of iguratimod in primary Sjögren’s syndrome patients. Int Ophthalmol. 2020 Jul 01;: Authors: Jiang W, Zhang L, Zhao Y, He X, Hu C, Liu Y Abstract PURPOSE: Primary Sjögren’s syndrome […]

Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren’s syndrome

https://link.springer.com/article/10.1007%2Fs00415-020-10033-z https://www.ncbi.nlm.nih.gov/pubmed/32613444?dopt=Abstract TITLE: Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren’s syndrome. DESCRIPTION: Related Articles Long-term efficacy of immunoglobulins in small fiber neuropathy related to Sjögren’s syndrome. J Neurol. 2020 Jul 01;: Authors: Pindi Sala T, Villedieu M, Damian L, Crave JC, Pautot V, Stojanovich L, Tervaert JWC, Cherin P, Belizna C […]

Insight into Salivary Gland Aquaporins: AQP5 represents a potential therapeutic target for the treatment of xerostomia (dry mouth)

https://www.mdpi.com/2073-4409/9/6/1547 https://www.ncbi.nlm.nih.gov/pubmed/32630469?dopt=Abstract TITLE: Insight into Salivary Gland Aquaporins. DESCRIPTION: Related Articles Insight into Salivary Gland Aquaporins. Cells. 2020 Jun 25;9(6): Authors: D’Agostino C, Elkashty OA, Chivasso C, Perret J, Tran SD, Delporte C Abstract The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key […]

Characterization of antiapoptotic microRNAs in primary Sjögren’s syndrome: potential targets for the treatment of pSS

https://onlinelibrary.wiley.com/doi/abs/10.1002/cbf.3569 https://www.ncbi.nlm.nih.gov/pubmed/32575162?dopt=Abstract TITLE: Characterization of antiapoptotic microRNAs in primary Sjögren’s syndrome. DESCRIPTION: Characterization of antiapoptotic microRNAs in primary Sjögren’s syndrome. Cell Biochem Funct. 2020 Jun 23;: Authors: Yang Y, Hou Y, Li J, Zhang F, Du Q Abstract During the development of primary Sjögren’s syndrome (pSS), aberrant expression of autoantigen is a hallmark event. To […]

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndrome

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02248-2 Research article Open Access Published: 22 June 2020 Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren’s syndrome Abstract Background The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome (pSS) at the transcriptome level. Methods We […]

Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases including Sjögren syndrome (SjS)

https://link.springer.com/article/10.1007%2Fs12016-020-08798-2 https://www.ncbi.nlm.nih.gov/pubmed/32557263?dopt=Abstract TITLE: Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases. DESCRIPTION: Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases. Clin Rev Allergy Immunol. 2020 Jun 17;: Authors: Jiang J, Zhao M, Chang C, Wu H, Lu Q Abstract Type I interferons (IFN-Is) are a very important group of […]

Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome

https://onlinelibrary.wiley.com/doi/abs/10.1111/jop.13070 https://www.ncbi.nlm.nih.gov/pubmed/32538490?dopt=Abstract TITLE: Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome. DESCRIPTION: Related Articles Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome. J Oral Pathol Med. 2020 Jun 15;: Authors: Moreno-Quispe LA, Serrano J, Virto L, Sanz M, Ramírez L, Fernández-Castro M, Hernández G, López-Pintor RM Abstract BACKGROUND: Primary Sjogren’s syndrome (pSS) is […]

Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren’s syndrome

https://www.sciencedirect.com/science/article/abs/pii/S0378874120314264?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32525066?dopt=Abstract TITLE: Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren’s syndrome. DESCRIPTION: Total glucosides of paeony (TGP) alleviates constipation and intestinal inflammation in mice induced by Sjögren’s syndrome. J Ethnopharmacol. 2020 Jun 07;:113056 Authors: Liu G, Wang Z, Li X, Liu R, Li B, Huang L, Chen […]

Efficacy of Belimumab in Primary Sjögren’s Syndrome: A Systematic Review

https://www.sciencedirect.com/science/article/pii/S1699258X20300760?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32451263?dopt=Abstract TITLE: Efficacy of Belimumab in Primary Sjögren’s Syndrome: A Systematic Review. DESCRIPTION: Related Articles Efficacy of Belimumab in Primary Sjögren’s Syndrome: A Systematic Review. Reumatol Clin. 2020 May 22;: Authors: Álvarez-Rivas N, Sang-Park H, Díaz Del Campo P, Fernández-Castro M, Corominas H, Andreu JL, Navarro-Compán V Abstract OBJECTIVE: To evaluate the efficacy and […]

Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren’s Syndrome

https://www.mdpi.com/2077-0383/9/5/1482 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290729/ https://www.ncbi.nlm.nih.gov/pubmed/32423153?dopt=Abstract TITLE: Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren’s Syndrome. DESCRIPTION: Related Articles Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren’s Syndrome. J Clin Med. 2020 May 14;9(5): Authors: Butryn M, Neumann J, Rolfes L, Bartels C, Wattjes MP, Mahmoudi N, Seeliger T, Konen […]

Immunobiology of T Cells in Sjögren’s Syndrome: summary of research progress to provide insights for clinical treatment

https://link.springer.com/article/10.1007/s12016-020-08793-7 https://www.ncbi.nlm.nih.gov/pubmed/32390096?dopt=Abstract TITLE: Immunobiology of T Cells in Sjögren’s Syndrome. DESCRIPTION: Immunobiology of T Cells in Sjögren’s Syndrome. Clin Rev Allergy Immunol. 2020 May 11;: Authors: Yao Y, Ma JF, Chang C, Xu T, Gao CY, Gershwin ME, Lian ZX Abstract Sjögren’s syndrome (SjS) is a systemic autoimmune disease marked by xerostomia (dry mouth), keratoconjunctivitis […]

Fibromyalgia, Sjogren’s & Depression: Linked?

https://www.tandfonline.com/doi/abs/10.1080/00325481.2020.1758426?journalCode=ipgm20 https://www.ncbi.nlm.nih.gov/pubmed/32314938?dopt=Abstract TITLE: Fibromyalgia, Sjogren’s & Depression: Linked? DESCRIPTION: Fibromyalgia, Sjogren’s & Depression: Linked? Postgrad Med. 2020 Apr 21;: Authors: Loganathan M, Ladani A, Lippmann S Abstract Health care has become increasingly fragmented, partly due to advancing medical technology. Patients are often managed by various specialty teams when presenting with symptoms that could be manifestations […]

Cysteine cathepsins as therapeutic targets in inflammatory diseases

https://www.tandfonline.com/doi/abs/10.1080/14728222.2020.1746765 Cysteine cathepsins as therapeutic targets in inflammatory diseases Matej Vizovišek,Eva Vidak,Urban Javoršek,Georgy Mikhaylov,Andreja Bratovš &Boris Turk Pages 573-588 | Received 23 Dec 2019, Accepted 20 Mar 2020, Accepted author version posted online: 31 Mar 2020, Published online: 06 Apr 2020 Download citation https://doi.org/10.1080/14728222.2020.1746765 CrossMark LogoCrossMark

JAK Inhibitors: Prospects in Connective Tissue Diseases including Sjögren’s Syndrome

https://link.springer.com/article/10.1007/s12016-020-08786-6 https://www.ncbi.nlm.nih.gov/pubmed/32222877?dopt=Abstract TITLE: JAK Inhibitors: Prospects in Connective Tissue Diseases. DESCRIPTION: Related Articles JAK Inhibitors: Prospects in Connective Tissue Diseases. Clin Rev Allergy Immunol. 2020 Mar 28;: Authors: You H, Xu D, Zhao J, Li J, Wang Q, Tian X, Li M, Zeng X Abstract The dysregulation of the JAK-STAT pathway is associated with various […]

Total glucosides of paeony (TGP) alleviates Sjogren’s syndrome through inhibiting inflammatory responses in mice

https://www.sciencedirect.com/science/article/abs/pii/S0944711320300362?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32402913?dopt=Abstract TITLE: Total glucosides of paeony (TGP) alleviates Sjogren’s syndrome through inhibiting inflammatory responses in mice. DESCRIPTION: Total glucosides of paeony (TGP) alleviates Sjogren’s syndrome through inhibiting inflammatory responses in mice. Phytomedicine. 2020 Mar 06;71:153203 Authors: Li B, Liu G, Liu R, He S, Li X, Huang L, Wang Z, Li Y, Chen Y, […]

Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome

https://www.nature.com/articles/s41419-020-2359-6 https://www.ncbi.nlm.nih.gov/pubmed/32139667?dopt=Abstract TITLE: Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome. DESCRIPTION: Related Articles Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome. Cell Death Dis. 2020 Mar 05;11(3):172 Authors: Hu L, Xu J, Wu T, Fan Z, Sun L, Liu Y, Li Y, […]

Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren’s syndrome

https://www.sciencedirect.com/science/article/pii/S1521694220300012?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/32067925?dopt=Abstract TITLE: Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren’s syndrome. DESCRIPTION: Targeted therapies in systemic sclerosis, myositis, antiphospholipid syndrome, and Sjögren’s syndrome. Best Pract Res Clin Rheumatol. 2020 Feb 15;:101485 Authors: van den Hoogen LL, van Laar JM Abstract Targeted therapies using biological disease-modifying antirheumatic drugs (bDMARDs) and small molecule synthetic […]

Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013496/ https://www.ncbi.nlm.nih.gov/pubmed/31963817?dopt=Abstract TITLE: Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions. DESCRIPTION: Related Articles Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions. Int J Mol Sci. 2020 Jan 19;21(2): Authors: de Paiva CS, Pflugfelder SC Abstract Sjögren Syndrome (SS) is an autoimmune disease that affects the exocrine glands, mainly salivary and lacrimal glands […]

Primary Sjogren’s syndrome: a great masquerader

https://casereports.bmj.com/content/12/12/e231802.full https://casereports.bmj.com/content/12/12/e231802 https://www.ncbi.nlm.nih.gov/pubmed/31888893?dopt=Abstract TITLE: Primary Sjogren’s syndrome: a great masquerader. DESCRIPTION: Related Articles Primary Sjogren’s syndrome: a great masquerader. BMJ Case Rep. 2019 Dec 29;12(12): Authors: Kumar N, Surendran D, Srinivas BH, Bammigatti C Abstract A 41-year-old woman presented with paresthesia and inability to walk for 7 days. She had history of fatigue, polyarthralgia and […]

A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren’s syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294338/ https://www.sciencedirect.com/science/article/pii/S0168365918306059?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/30359668?dopt=Abstract TITLE: A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren’s syndrome. DESCRIPTION: Related Articles A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren’s syndrome. J Control Release. 2018 12 28;292:183-195 Authors: Guo H, Lee […]

A213, a RORγt antagonist, improves Sjögren’s syndrome-like sialadenitis through downregulation of CD25

https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13255 https://www.ncbi.nlm.nih.gov/pubmed/31837283?dopt=Abstract TITLE: RORγt antagonist improves Sjögren’s syndrome-like sialadenitis through downregulation of CD25. DESCRIPTION: Related Articles RORγt antagonist improves Sjögren’s syndrome-like sialadenitis through downregulation of CD25. Oral Dis. 2020 May;26(4):766-777 Authors: Ono Y, Tsuboi H, Moriyama M, Asashima H, Kudo H, Takahashi H, Honda F, Abe S, Kondo Y, Takahashi S, Matsumoto I, Nakamura S, […]

Sjögren’s syndrome: Old and new therapeutic targets

https://www.sciencedirect.com/science/article/abs/pii/S0896841119307267 Sjögren’s syndrome: Old and new therapeutic targets Academy of Athens, Chair Medical Sciences/Immunology, Greece Received 6 November 2019, Accepted 10 November 2019, Available online 9 December 2019.

LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjögren’s syndrome-like autoimmune response

https://www.sciencedirect.com/science/article/pii/S0896841119306006?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31757716?dopt=Abstract TITLE: LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjögren’s syndrome-like autoimmune response. DESCRIPTION: Related Articles LncRNA PVT1 links Myc to glycolytic metabolism upon CD4+ T cell activation and Sjögren’s syndrome-like autoimmune response. J Autoimmun. 2019 Nov 19;:102358 Authors: Fu J, Shi H, Wang B, Zhan T, Shao […]

Associations of Anti-Aquaporin 5 Autoantibodies with Features of Sjögren’s Syndrome: Screening may reveal subgroups of SS for targeted therapy

https://www.mdpi.com/2077-0383/8/11/1863 https://www.ncbi.nlm.nih.gov/pubmed/31684196?dopt=Abstract TITLE: Associations of Anti-Aquaporin 5 Autoantibodies with Serologic and Histopathological Features of Sjögren’s Syndrome. DESCRIPTION: Related Articles Associations of Anti-Aquaporin 5 Autoantibodies with Serologic and Histopathological Features of Sjögren’s Syndrome. J Clin Med. 2019 Nov 03;8(11): Authors: Jeon S, Lee J, Park SH, Kim HD, Choi Y Abstract Biomarkers to stratify the complex […]

Common and rare forms of vasculitis associated with Sjögren’s syndrome

https://www.ncbi.nlm.nih.gov/pubmed/31644467?dopt=Abstract TITLE: Common and rare forms of vasculitis associated with Sjögren’s syndrome. DESCRIPTION: Common and rare forms of vasculitis associated with Sjögren’s syndrome. Curr Opin Rheumatol. 2019 Oct 21;: Authors: Argyropoulou OD, Tzioufas AG Abstract PURPOSE OF REVIEW: Although uncommon, systemic vasculitis is one of the most severe extraglandular manifestations of primary Sjögren’s syndrome (pSS) […]

Primary Sjögren’s syndrome and the eye: update regarding pathogenesis, diagnosis, investigative procedures, and treatment options

https://www.surveyophthalmol.com/article/S0039-6257(19)30283-8/fulltext https://www.ncbi.nlm.nih.gov/pubmed/31634487?dopt=Abstract TITLE: Primary Sjögren’s syndrome and the eye. DESCRIPTION: Primary Sjögren’s syndrome and the eye. Surv Ophthalmol. 2019 Oct 18;: Authors: Bjordal O, Norheim KB, Rødahl E, Jonsson R, Omdal R Abstract Primary Sjögren syndrome is an autoimmune disease that mainly affects exocrine glands such as the salivary and lacrimal glands. In addition, systemic […]

Immune checkpoint molecules: Possible future therapeutic implications in autoimmune diseases such as Sjögren’s syndrome

https://www.sciencedirect.com/science/article/abs/pii/S0896841119305712?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31564474?dopt=Abstract TITLE: Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases. DESCRIPTION: Related Articles Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases. J Autoimmun. 2019 11;104:102333 Authors: Huang C, Zhu HX, Yao Y, Bian ZH, Zheng YJ, Li L, Moutsopoulos HM, Gershwin ME, Lian ZX Abstract During host immune response, an […]

Saliva microbiome in primary Sjögren’s syndrome reveals distinct set of disease-associated microbes

https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.13191 https://www.ncbi.nlm.nih.gov/pubmed/31514257?dopt=Abstract TITLE: Saliva microbiome in primary Sjögren’s syndrome reveals distinct set of disease-associated microbes. DESCRIPTION: Related Articles Saliva microbiome in primary Sjögren’s syndrome reveals distinct set of disease-associated microbes. Oral Dis. 2020 Mar;26(2):295-301 Authors: Sharma D, Sandhya P, Vellarikkal SK, Surin AK, Jayarajan R, Verma A, Kumar A, Ravi R, Danda D, Sivasubbu S, […]

Biologics in Sjögren’s syndrome

https://www.sciencedirect.com/science/article/abs/pii/S1043661819310424?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31415917?dopt=Abstract TITLE: Biologics in Sjögren’s syndrome. DESCRIPTION: Related Articles Biologics in Sjögren’s syndrome. Pharmacol Res. 2019 09;147:104389 Authors: Skarlis C, Marketos N, Mavragani CP Abstract The use of biologic disease modifying antirheumatic drugs (bDMARDs) in systemic autoimmune diseases such as rheumatoid arthritis and at a lesser extent in lupus, has been well established. In […]

Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome: CatS inhibition may represent a promising novel treatment strategy in pSS

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-1955-2 https://www.ncbi.nlm.nih.gov/pubmed/31319889?dopt=Abstract TITLE: Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome. DESCRIPTION: Related Articles Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome. Arthritis Res Ther. 2019 07 18;21(1):175 Authors: Hargreaves P, Daoudlarian D, Theron M, Kolb FA, Manchester Young M, Reis […]

Potential therapeutic applications of exosomes in different autoimmune diseases including Sjogren’s syndrome

https://www.sciencedirect.com/science/article/abs/pii/S1521661619301548?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31228581?dopt=Abstract TITLE: Potential therapeutic applications of exosomes in different autoimmune diseases. DESCRIPTION: Related Articles Potential therapeutic applications of exosomes in different autoimmune diseases. Clin Immunol. 2019 08;205:116-124 Authors: Xu H, Jia S, Xu H Abstract Autoimmune diseases are caused by self-immune responses to autoantigens, which damage body tissues and severely affect the patient’s quality […]

Sjögren’s syndrome update: Clinical and therapeutic aspects

https://www.sciencedirect.com/science/article/abs/pii/S0248866319304242?via%3Dihub https://www.ncbi.nlm.nih.gov/pubmed/31027874?dopt=Abstract TITLE: [Sjögren’s syndrome update: Clinical and therapeutic aspects]. DESCRIPTION: Related Articles [Sjögren’s syndrome update: Clinical and therapeutic aspects]. Rev Med Interne. 2019 Jul;40(7):433-439 Authors: Nocturne G Abstract Sjögren’s syndrome (SS) is a systemic orphan disease. It is characterized by the involvement of epithelial tissues leading to the term of autoimmune epithelitis. New classification […]