Tag: CP-25

CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases

https://www.nature.com/articles/s41401-020-00510-6 https://www.ncbi.nlm.nih.gov/pubmed/32884075?dopt=Abstract TITLE: CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. DESCRIPTION: Related Articles CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacol Sin. 2020 Sep […]

Study identifies CP-25 as a potential drug for the treatment of primary Sjögren’s syndrome

New research published in Nature’s Laboratory Investigation shows that CP-25 “increased saliva flow, alleviated the salivary gland indexes, and improved tissue integrity” in a mouse model of primary Sjogren’s syndrome. Researchers “identified the underlying mechanisms of the therapeutic effect of CP-25 and provided an experimental foundation for CP-25 as a potential drug in the treatment […]

CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration

https://www.nature.com/articles/s41374-020-0453-0 https://www.ncbi.nlm.nih.gov/pubmed/32620868?dopt=Abstract TITLE: CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration. DESCRIPTION: Related Articles CP-25 alleviates antigen-induced experimental Sjögren’s syndrome in mice by inhibiting JAK1-STAT1/2-CXCL13 signaling and interfering with B-cell migration. Lab Invest. 2020 Jul 03;: Authors: Wu H, Chen X, Gu F, Zhang P, Xu […]